Grants to USA Small Businesses for Research and Development
Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)
Agency
Federal
GrantWatch ID#
215601
Funding Source
U.S. Department of Health and Human Services (HHS) - National Institutes of Health (NIH)
CFDA Number: 93.113, 93.279, 93.286, 93.879, 93.350, 93.213, 93.233, 93.837, 93.838, 93.839, 93.840, 93.121, 93.847, 93.859, 93.242, 93.361, 93.855, 93.172, 93.273, 93.853, 93.846, 93.394, 93.865, 93.393, 93.395, 93.173, 93.867, 93.307, 93.351, 93.866, 93.313
Funding or PIN Number: PA-27-102
Geographic Focus
All USA
Important Dates
Deadline: 09/05/26 5:00 PM Submitter's local time
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Grant Description
Grants to USA small businesses for research and development that will culminate in viable technology transfers. Applicants are advised that required registrations may take several weeks to complete. Funding is intended for projects that have a strong potential for commercialization.
The Small Business Technology Transfer (STTR) grant program helps United States small business concerns (SBCs) that partner with a nonprofit research institution bring scientific innovations to the marketplace. The STTR program supports feasibility studies to later stage research and development (R&D) needed to develop a commercial product.
The STTR Program supports projects through multiple phases:
- Phase I: Establish the technical merit and feasibility of the proposed R&D.
- Phase II: Continue R&D to advance toward commercialization.
After Phase II, NIH expects small business concerns (SBCs) to fully commercialize the product or technology using non-SBIR/STTR funds (federal or non-federal).
This NOFO accepts STTR Phase I, Phase II, Direct to Phase II (NIH only), and Fast-Track (NIH-only), grant applications from eligible United States SBCs.
- NIH Fast-Track: The NIH Fast-Track allows both Phase I and Phase II of a project to be submitted and reviewed together as one application to reduce or eliminate the funding gap between phases.
- NIH Direct to Phase II: Small businesses that have already demonstrated scientific and technical merit and feasibility but have not received a Phase I SBIR or STTR for that project, can apply for a Direct to Phase II award. The NIH will accept Direct to Phase II applications regardless of the funding source for the work on which the proposed Phase II research is based.
Categories
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Recipient
Eligibility
- Small businesses
Additional Eligibility Criteria
Only United States small business concerns (SBCs) are eligible to submit applications for this opportunity. A small business concern is one that, at the time of award of Phase I and Phase II, meets all of the following criteria:
1. Is organized for profit, with a place of business located in the United States, which operates primarily within the United States or which makes a significant contribution to the United States economy through payment of taxes or use of American products, materials or labor.
2. Is in the legal form of an individual proprietorship, partnership, limited liability company, corporation, joint venture, association, trust or cooperative, except that where the form is a joint venture, there must be less than 50 percent participation by foreign business entities in the joint venture.
3. Must be one of the following:
a. Be a concern which is more than 50% directly owned and controlled by one or more individuals (who are citizens or permanent resident aliens of the United States), other business concerns (each of which is more than 50% directly owned and controlled by individuals who are citizens or permanent resident aliens of the United States), an Indian tribe, ANC or NHO (or a wholly owned business entity of such tribe, ANC or NHO), or any combination of these; OR
b. Be a joint venture in which each entity to the joint venture must meet the requirements set forth in paragraph 3(a) of this section.
4. Has, including its affiliates, not more than 500 employees.
1. Is organized for profit, with a place of business located in the United States, which operates primarily within the United States or which makes a significant contribution to the United States economy through payment of taxes or use of American products, materials or labor.
2. Is in the legal form of an individual proprietorship, partnership, limited liability company, corporation, joint venture, association, trust or cooperative, except that where the form is a joint venture, there must be less than 50 percent participation by foreign business entities in the joint venture.
3. Must be one of the following:
a. Be a concern which is more than 50% directly owned and controlled by one or more individuals (who are citizens or permanent resident aliens of the United States), other business concerns (each of which is more than 50% directly owned and controlled by individuals who are citizens or permanent resident aliens of the United States), an Indian tribe, ANC or NHO (or a wholly owned business entity of such tribe, ANC or NHO), or any combination of these; OR
b. Be a joint venture in which each entity to the joint venture must meet the requirements set forth in paragraph 3(a) of this section.
4. Has, including its affiliates, not more than 500 employees.
Ineligible
Small business concerns that are more than 50% owned by multiple venture capital operating companies, hedge funds, private equity firms, or any combination of these are not eligible to apply to the NIH STTR program.
Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Only accepting applications that do not propose clinical trials.
Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Only accepting applications that do not propose clinical trials.
Pre-Application Information
Application Due Dates (due by 5:00 PM local time of applicant organization):
• September 05, 2026
• January 05, 2027
• April 05, 2027
Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.
Required Registrations:
Applicants must have an active System for Award (SAM) registration (https://sam.gov/content/entity-registration) which provides a Unique Entity Identifier (UEI), and Grants.gov account to apply. Creating a Grants.gov account can be completed online in minutes (https://www.grants.gov/register), but SAM registration may take several weeks. Therefore, an applicant’s registration should be done in sufficient time to ensure it does not impact the entity’s ability to meet required application submission deadlines.
Full Announcement:
https://files.simpler.grants.gov/opportunities/ee37f2de-b959-4b45-86a9-43d06c944f24/attachments/5295c0e4-bffd-4a53-911e-4cfdd9567e71/PA-27-102-Revised-Full-Announcement.html
View on Grants.gov:
https://www.grants.gov/search-results-detail/359757
• September 05, 2026
• January 05, 2027
• April 05, 2027
Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.
Required Registrations:
Applicants must have an active System for Award (SAM) registration (https://sam.gov/content/entity-registration) which provides a Unique Entity Identifier (UEI), and Grants.gov account to apply. Creating a Grants.gov account can be completed online in minutes (https://www.grants.gov/register), but SAM registration may take several weeks. Therefore, an applicant’s registration should be done in sufficient time to ensure it does not impact the entity’s ability to meet required application submission deadlines.
Full Announcement:
https://files.simpler.grants.gov/opportunities/ee37f2de-b959-4b45-86a9-43d06c944f24/attachments/5295c0e4-bffd-4a53-911e-4cfdd9567e71/PA-27-102-Revised-Full-Announcement.html
View on Grants.gov:
https://www.grants.gov/search-results-detail/359757
Number of Grants
The number of awards is contingent upon NIH appropriations, reauthorization and extension of the STTR program, and the submission of a sufficient number of meritorious applications.
Estimated Size of Grant
The budget guidelines are the same for both the SBIR and STTR programs, but individual NIH Institutes and Centers can set their own budget limits.
• A Phase I budget is $323,090 for a project timeline between 6 months to 2 years.
• A Phase II budget is $2,153,927 for a project timeline between 1 to 3 years.
See https://seed.nih.gov/small-business-funding/small-business-program-basics/understanding-sbir-sttr#Budget-and-timelines-for-funding
• A Phase I budget is $323,090 for a project timeline between 6 months to 2 years.
• A Phase II budget is $2,153,927 for a project timeline between 1 to 3 years.
See https://seed.nih.gov/small-business-funding/small-business-program-basics/understanding-sbir-sttr#Budget-and-timelines-for-funding
Contact Information
There are several options available to submit your application through Grants.gov to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity.
1. Use the NIH ASSIST system to prepare, submit and track your application online. https://public.era.nih.gov/assist/landing.era?tabId=0819b5fc-46b7-4f02-b6b7-127e5a4e19fa
2. Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants.gov and eRA Commons to track your application. Check with your institutional officials regarding availability.
3. Use Grants.gov Workspace to prepare and submit your application and eRA Commons to track your application.
For a full list of scientific/research contacts, see the Full Grant Text RFP link.
eRA Service Desk (Questions regarding ASSIST, eRA Commons, application errors and warnings, documenting system problems that threaten submission by the due date, and post-submission issues)
Finding Help Online: https://www.era.nih.gov/need-help (preferred method of contact)
Telephone: 301-402-7469 or 866-504-9552 (Toll Free)
Scientific/Research Contact(s)
NIH SEED (Small business Education and Entrepreneurial Development)
Telephone: 301-827- 8595
Email: SEEDinfo@nih.gov
Grants.gov Customer Support (Questions regarding Grants.gov registration and Workspace)
Contact Center Telephone: 800-518-4726
Email: support@grants.gov
1. Use the NIH ASSIST system to prepare, submit and track your application online. https://public.era.nih.gov/assist/landing.era?tabId=0819b5fc-46b7-4f02-b6b7-127e5a4e19fa
2. Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants.gov and eRA Commons to track your application. Check with your institutional officials regarding availability.
3. Use Grants.gov Workspace to prepare and submit your application and eRA Commons to track your application.
For a full list of scientific/research contacts, see the Full Grant Text RFP link.
eRA Service Desk (Questions regarding ASSIST, eRA Commons, application errors and warnings, documenting system problems that threaten submission by the due date, and post-submission issues)
Finding Help Online: https://www.era.nih.gov/need-help (preferred method of contact)
Telephone: 301-402-7469 or 866-504-9552 (Toll Free)
Scientific/Research Contact(s)
NIH SEED (Small business Education and Entrepreneurial Development)
Telephone: 301-827- 8595
Email: SEEDinfo@nih.gov
Grants.gov Customer Support (Questions regarding Grants.gov registration and Workspace)
Contact Center Telephone: 800-518-4726
Email: support@grants.gov
RFP & Supporting Documents
