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Grants to USA Nonprofits, For-Profits, Agencies, and IHEs for Research Addressing Pain Relief

HEAL Initiative Integrated Basic and Clinical Team-based Research in Pain (RM1 Clinical Trial Optional)


GrantWatch ID#

Funding Source
U.S. Department of Health and Human Services (HHS) - National Institutes of Health (NIH)
CFDA Number: 93.121, 93.233, 93.273, 93.393, 93.395, 93.396, 93.399, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, 93.865, 93.866
Funding or PIN Number: RFA-NS-22-069
Array ( [0] => American Samoa (USA); [1] => Guam (USA); [2] => Puerto Rico (USA); [3] => Virgin Islands (USA); [4] => Northern Mariana Islands (USA); )

Geographic Focus
USA Territories: American Samoa (USA);   Guam (USA);   Puerto Rico (USA);   Virgin Islands (USA);   Northern Mariana Islands (USA);

Important Dates
LOI Date: 01/13/24
Deadline: 02/12/24 5:00 PM Save

Grant Description
Grants to USA and Territories nonprofit and for-profit organizations, government agencies, and IHEs for research related to non-addictive pain relief. Applicants are advised that required registrations must be completed prior to submitting a grant application. Funding is intended for studies to develop non-opioid solutions to pain management.

More than 25 million Americans suffer from daily chronic pain, a highly debilitating medical condition that is complex and difficult to manage. In recent decades, there has been an overreliance on the prescription of opioids for chronic pain despite their poor ability to improve function and high addiction liability. This contributed to a significant and alarming epidemic of opioid overdose deaths and addictions. Innovative scientific solutions to develop alternative pain treatment options are thus critically needed.

Through targeted research efforts, the NIH’s Helping to End Addiction Long-term (HEAL) Initiative® aims to support the development of safe and effective therapeutics and devices to treat pain with little or no addiction liability. This funding opportunity announcement (FOA) is designed to support integrated efforts of three or more (up to six) PDs/PIs to pursue bold, impactful, and challenging research in basic and clinical pain domains to understand the biology of specific human pain conditions as well as pain associated with various diseases/disorders and pain across the lifespan, including mechanistic underpinning of heterogeneity and stratification of patients with specific pain conditions and co-morbidities. The research approach should be interdisciplinary in nature, and the research teams are expected to establish a common goal that requires collaboration, synergy, and managed team interactions. Proposed research should support a cohesive, single, well-integrated research plan with a singular focus, one set of aims, and a budget without subprojects. Proposed research should not represent a collection of individual efforts or parallel projects. Teams must leverage appropriate multi-disciplinary expertise to develop new principles and methods for experimentation, analysis, and interpretation. Teams are encouraged to consider transformative objectives with defined 5-year outcomes that will produce major advances in the understanding of human pain conditions and are likely to improve strategies for effective management of human pain.

This FOA encourages a team of investigators with expertise in multiple disciplines to pursue coordinated research that could integrate diverse areas of expertise under one umbrella, including (but not limited to):

  • Clinical pain management
  • Clinical pain research
  • Preclinical/basic pain biology and modeling
  • Human psychology
  • Specific disease and/or pathological conditions (both human and preclinical models)
  • Animal behavior,
  • Artificial Intelligence
  • Data science

Projects should be focused on a specific pain condition, including but not limited to acute pain, chronic pain, painful neuropathy, musculoskeletal pain, headache, osteoarthritis, diabetic neuropathy, chemotherapy-induced neuropathy, eye pain, sickle-cell pain, post-surgical pain, cancer pain, visceral pain, obstetric pain, gynecologic pain, post stroke pain, myofascial pain, painful disorders of the orofacial region, pain co-occurring with substance use disorders, pain conditions across the lifespan including in the context of aging, and other conditions will be considered. Applications focused on conditions that are commonly treated with opioids and/or other substances with high misuse potential and/or with high addiction potential are a high program priority for the NIH HEAL Initiative®.

For additional information regarding examples, see URL for Full Text (RFP) link, below. 


  • City or township governments
  • County governments
  • For profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities/Indian housing authorities
  • Others (see text field entitled "Additional Eligibility Criteria" for clarification)
  • Small businesses
  • Special district governments
  • State governments

Additional Eligibility Criteria
Higher Education Institutions
- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education

The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)

Nonprofits Other Than Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)

For-Profit Organizations
- Small Businesses
- For-Profit Organizations (Other than Small Businesses)

Local Governments
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)

Federal Government
- Eligible Agencies of the Federal Government
- U.S. Territory or Possession

- Independent School Districts
- Public Housing Authorities/Indian Housing Authorities
- Native American Tribal Organizations (other than Federally recognized tribal governments)
- Faith-based or Community-based Organizations
- Regional Organizations
- Non-domestic (non-U.S.) Entities (Foreign Institutions)

Foreign Institutions
- Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.
- Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.
- Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from diverse backgrounds, including underrepresented racial and ethnic groups, individuals with disabilities, and women are always encouraged to apply for NIH support.

Applications that propose extrapolations of a single line of research or propose parallel but independent advancement of different areas in pain are not appropriate for this FOA.

Annual inflationary increases are not allowed.

Pre-Application Information
Application due dates:
- February 14, 2023
- June 14, 2023
- October 13, 2023
- February 12, 2024

LOIs are due 30 days before the application due date. Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review.

All applications are due by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Applicants are strongly encouraged to consult with NIH HEAL Initiative® program staff as plans for an application are being developed.

Applicant organizations may submit more than one application, provided that each application is scientifically distinct.

Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. The NIH Policy on Late Submission of Grant Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission:
- System for Award Management (SAM):
- NATO Commercial and Government Entity (NCAGE) Code:
- Unique Entity Identifier (UEI)- A UEI is issued as part of the registration process. The same UEI must be used for all registrations, as well as on the grant application.
- eRA Commons:

There are several options available to submit your application through to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity:
- Use the NIH ASSIST system to prepare, submit and track your application online.
- Use an institutional system-to-system (S2S) solution to prepare and submit your application to and eRA Commons to track your application. Check with your institutional officials regarding availability.
- Use Workspace to prepare and submit your application and eRA Commons to track your application.

It is critical that applicants follow the instructions in the Research (R) Instructions in the SF424 (R&R) Application Guide (, except where instructed to do otherwise (in this FOA or in a Notice from NIH Guide for Grants and Contracts:

How to Apply guide:

For additional relevant links, see URL for Full Text (RFP) link, below.

View this opportunity on

Number of Grants
NIH intends to fund an estimate of 3-4 awards for fiscal year 2023.

Estimated Size of Grant
Application budgets should not exceed $1,000,000 direct costs per year.

Term of Contract
Applications may request up to five years of support.

Contact Information

The letter of intent should be sent to:
D.P. Mohapatra, Ph.D.
Telephone: 301-496-9964
Fax: 301-402-2060

For application submission contacts and scientific/research contacts, and other relevant contacts, see URL for Full Text (RFP) link, below.

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